Micronization of Organic Drugs and Discussion of Structure/ Dissolution Rate Changes by Microemulsion Systems
Date Issued
2011
Date
2011
Author(s)
Fan, Yueh-Lin
Abstract
Abstract
For poor solubility in water or lower bioavailability organic drugs, using microemulsion systems to micronize or structurally change the drugs, is both a direct and safe method to enhance the dissolution rate and bioavailability of the drugs in the human body. In this research, the microemulsion systems were utilized with temperature changing processes to modify organic drugs.
Microemulsion systems were used to change the structure and dissolution rate of organic drugs. Ionic and nonionic microemulsions and pure solvents environments were investigated. The study was aimed to correlate the structural change and dissolution rate change of organic drugs after recrystallizing from microemulsions.
In the research, we found that microemulsion systems could lead organic drugs to a hydrated state. For carbamazepine, piroxicam, sulfaguanidine, theophylline, nitrofurantoin, and diclofenac sodium, every microemulsion system could be changed from anhydrate to hydrate. However for diflunisal, only specific microemulsion conditions could change to hydrated states.
For drugs with polymorphism, microemulsion systems could change to different structures. Microemulsion systems could change sulfathiazole from Form-IV to Form-III and improve its dissolution rate.
Microemulsion systems can also micronize organic compounds. Mitotane and ibuprofen were micronized by microemulsion system. Therefore, after microemulsion process they performed better dissolution rate.
The results suggest that the microemulsion systems can cause the organic drugs to change structure or become hydrate crystals. The dissolution rates of modified crystals change depending on the conditions. Crystallization from microemulsion media enables one to obtain the drug with a predictable structure, morphology, and dissolution rate.
Subjects
Microemulsion
Crystallization
Polymorph
Hydrate
Morphology
Dissolution Rate
Type
thesis
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