Longitudinal analysis of liver transplant candidates for hepatocellular carcinoma in a single center.
Journal
Langenbeck's archives of surgery
Series/Report No.
Langenbeck's archives of surgery
Journal Volume
409
Journal Issue
1
Start Page
143
ISSN
1435-2451
Date Issued
2024-04-29
Author(s)
DOI
10.1007/s00423-024-03336-6
Abstract
Background: Wailitst lost is an critical issue and we investigated the long-term effect of insufficient liver functional reserve at liver transplantation evaluation on waitlist outcomes in patients with hepatocellular carcinoma (HCC).
Methods: Clinical data of patients with HCC waitlisted for liver transplantation were retrospectively collected from a single hospital cohort during the period from 2014 to 2021. Parameters of liver reserve, including cirrhosis, Child-Pugh grade, and Model for End-Stage Liver Disease (MELD) scores, were analyzed for patient survival, after adjustment for tumor factors.
Results: Of 292 eligible patients, 94.2% had cirrhosis, 55.8% had Child-Pugh grade B or C, and the median MELD score was 13.2. The median follow-up time was 2.2 years, with a dropout rate of 62.7%. Eighty-nine candidates (30.5%) eventually received liver transplant, including 67 from live donors. The estimated 1-year mortality rate reached 40.6% in 203 patients who remained on the waitlist without receiving a transplant, of whom 143 died. Most deaths were attributed to liver failure (37.1%) and cancer death (35.7%). After we adjusted for tumor confounders, including alpha fetoprotein, primary HCC stage, tumor number at evaluation, and sequential cancer treatment before and while waiting, hazard ratios (HRs) for patient survival were 1.69 (95% confidence interval, 1.18-2.41) for cirrhotic stage B or C, 1.07 (1.04-1.10) for MELD scores, and 1.14 (1.04-1.25) for tumor size at transplant evaluation. Transplantation was a protective disease modifier with adjusted HR 0.22 (0.14-0.33).
Conclusion: Insufficient liver functional reserve poses more risk than expected to liver transplant waitlist outcomes with HCC.
Subjects
Cirrhosis
Hepatocellular carcinoma
Liver failure
Liver transplantation
Reserve
waitlist outcome
SDGs
Type
journal article