Identification of regulatory host genes involved in sigma virus replication using RNAi knockdown in drosophila
Journal
Insects
Journal Volume
10
Journal Issue
10
Date Issued
2019
Author(s)
Abstract
. Our study proved that host immunity influences viral replication, even in persistent infection. Knocking down the key components of the immune process deactivates immune controls, thus facilitating viral expression and replication. We propose that the immunity system of D. melanogaster regulates the replication of the sigma virus by affecting the L gene expression. Studies have shown minimal host-virus interaction in persistent infection. However, our study demonstrated that the immunity continued to affect viral replication even in persistent infection because knocking down the key components of the immune process disabled the relevant immune controls and facilitated viral expression and replication.
SDGs
Type
journal article