Prenatal diagnosis and treatment of fetal long QT syndrome: A case report
Journal
Prenatal Diagnosis
Journal Volume
22
Journal Issue
13
Pages
1209-1212
Date Issued
2002
Author(s)
Abstract
We report a case of a fetus presenting with bradycardia, intermittent atrioventricular (AV) block, ventricular tachycardia (VT) and the signs of fetal congestive heart failure (ascites and scrotal hydrocele) during midgestation. Prenatal treatment with β-adrenergic blocker (propranolol) and digitalis glycosides was prescribed because of suspicion of long QT syndrome occurring with fetal congestive heart failure. The male baby was born at 39 weeks of gestation and showed a prolonged QT interval (QTc = 492 ms) and frequent variable AV block or alternating left and right bundle branch block, depending on the atrial rate. Prenatal administration of lidocaine failed to correct the fetal VT. Conversely, propranolol decreased the attack frequency of fetal VT. Postnatal administration of the K+ channel opener (nicorandil) successfully shortened the QT interval and improved the outcome. ? 2002 John Wiley & Sons, Ltd.
SDGs
Other Subjects
beta adrenergic receptor blocking agent; digitalis glycoside; lidocaine; potassium channel stimulating agent; propanol; article; ascites; atrioventricular block; bradycardia; case report; clinical trial; congestive heart failure; controlled clinical trial; controlled study; fetus; gestational age; heart ventricle tachycardia; human; hydrocele; long QT syndrome; male; postnatal care; prenatal diagnosis; priority journal; QT interval; scrotum disorder; Adult; Bradycardia; Bundle-Branch Block; Electrocardiography; Female; Fetal Diseases; Heart Block; Heart Failure, Congestive; Humans; Infant, Newborn; Lidocaine; Long QT Syndrome; Male; Nicorandil; Pregnancy; Pregnancy Trimester, Second; Propranolol; Tachycardia, Ventricular; Ultrasonography, Prenatal; Vasodilator Agents; Digitalis
Type
journal article