MoS2-Gd Chelate Magnetic Nanomaterials with Core-Shell Structure Used as Contrast Agents in in Vivo Magnetic Resonance Imaging
Journal
ACS Applied Materials and Interfaces
Journal Volume
8
Journal Issue
3
Pages
1827-1835
Date Issued
2016
Author(s)
Abstract
Despite their frequent usages as contrast agents for in vivo MRI imaging, paramagnetic molecules continue to suffer from low resolution, physicochemical instability, and high toxicity. Herein, we present a molybdenum disulfide and gadolinium complex, as an alternative core-shell magnetic nanomaterial that exhibits enhanced paramagnetic property; 4.5-times longer water proton spin-lattice relaxation time (T1) when compared to commercial gadolinium contrast agents; as well as lowered toxicity, extended blood circulation time, increased stability, and desirable excretion characteristic. Transmission electron microscopy (TEM) revealed smooth core-shell nanoparticles 100 nm in size with a shell width of approximately 10 nm. These findings suggest that the synthesized nanomaterial possesses high potential as a positive contrast agent for the enhancement of MRI imaging. ? 2015 American Chemical Society.
Subjects
contrast agents; core-shell structure; enhanced T1 value; in vivo imaging enhanced excretion; molybdenum disulfide nanoparticle
Other Subjects
Cardiovascular system; Gadolinium; High resolution transmission electron microscopy; Magnetic materials; Magnetic resonance imaging; Magnetism; Molybdenum compounds; Nanoparticles; Nanostructured materials; Paramagnetism; Physiology; Toxicity; Transmission electron microscopy; Contrast agent; Core shell structure; Enhanced excretion; Enhanced T; Molybdenum disulfide; Shells (structures); chelating agent; contrast medium; disulfide; gadolinium; molybdenum; molybdenum disulfide; nanomaterial; animal; chemistry; drug effects; female; human; Institute for Cancer Research mouse; magnetism; nuclear magnetic resonance imaging; particle size; procedures; signal processing; static electricity; thermodynamics; ultrastructure; umbilical vein endothelial cell; X ray photoelectron spectroscopy; Animals; Chelating Agents; Contrast Media; Disulfides; Female; Gadolinium; Human Umbilical Vein Endothelial Cells; Humans; Magnetic Phenomena; Magnetic Resonance Imaging; Mice, Inbred ICR; Molybdenum; Nanostructures; Particle Size; Photoelectron Spectroscopy; Signal Processing, Computer-Assisted; Static Electricity; Thermodynamics
Type
journal article