Clinical features of atypical Kawasaki disease
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
35
Journal Issue
1
Pages
57-60
Date Issued
2002
Author(s)
Abstract
From 1989 through 1998, a total of 132 children admitted to the National Taiwan University Hospital were identified as having Kawasaki disease. Twenty (15%) of them did not meet the diagnostic criteria of Kawasaki disease, but were considered atypical Kawasaki based on the specific clinical signs and exclusion of other causes by serologic study and culture result. The patients' age ranged from 5 months to 11 years, with a mean of 22.2 months and a median of 15 months. The male to female ratio was 1.9:1: Twenty-five percent (5/20) of them had coronary arterial lesion. No difference was found in the age distribution, sex, and rate of coronary artery involvement between typical and atypical Kawasaki disease. All patients were treated with intravenous immunoglobulin and aspirin except for 2 patients. At follow-up, patients with coronary arterial lesions had a prognosis as good as those with typical Kawasaki disease. According to these observations, atypical Kawasaki disease may be part of Kawasaki disease occurring via the same pathogenesis, but has incomplete manifestation. Clinical practitioners should have a high index of suspicion to diagnose and initiate prompt treatment to reduce the comorbidity of coronary arterial disease in patients with atypical Kawasaki disease.
Other Subjects
acetylsalicylic acid; immunoglobulin G; article; child; comorbidity; conjunctivitis; coronary artery disease; female; fever; human; infant; lymphadenopathy; major clinical study; male; mucocutaneous lymph node syndrome; pathogenesis; rash; Child; Child, Preschool; Female; Humans; Immunoglobulins, Intravenous; Infant; Male; Mucocutaneous Lymph Node Syndrome; Prevalence; Recurrence
Type
journal article