Antihypertriglyceridemia and anti-inflammatory activities of Monascus -fermented dioscorea in streptozotocin-induced diabetic rats
Resource
EXPERIMENTAL DIABETES RESEARCH, 2011, 710635
Journal
Experimental Diabetes Research
Journal Volume
2011
Date Issued
2011
Author(s)
Abstract
The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple. Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65mg/kg i.p.). RMD was administered daily starting six weeks after disease onset. Throughout the experimental period, significantly (P<.05) lowered plasma glucose, triglyceride, cholesterol, free fatty acid and low density lipoprotein levels were observed in the RMD-treated groups. The RMD-treated diabetic rats showed higher activities of glutathione disulfide reductase, glutathione reductase, catalase and superoxide dismutase (P<.05) in the pancreas compared with the diabetic control rats. RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1, IL-6, interferon- and tumor necrosis factor-. Pancreatic -cells damaged by STZ in the RMD supplemented groups were ameliorated. The results of this study clearly demonstrated that RMD possesses several treatment-oriented properties, including the control of hyperglycemia, antioxidant effects, pancreatic -cell protection and anti-inflammatory effects. Considering these observations, it appears that RMD may be a useful supplement to delay the development of diabetes and its complications. Copyright ? 2011 Yeu-Ching Shi et al.
SDGs
Other Subjects
antiinflammatory agent; antilipemic agent; catalase; cholesterol; fatty acid; gamma interferon; glucose; glutathione disulfide; glutathione reductase; interleukin 1beta; interleukin 6; low density lipoprotein; red mold dioscorea; streptozocin; superoxide dismutase; triacylglycerol; tumor necrosis factor alpha; unclassified drug; antiinflammatory agent; catalase; cholesterol; fatty acid; gamma interferon; glutathione reductase; insulin; interleukin 1beta; interleukin 6; low density lipoprotein; superoxide dismutase; triacylglycerol; tumor necrosis factor alpha; animal experiment; animal model; antihypertriglyceridemia activity; antiinflammatory activity; antioxidant activity; article; cell protection; cholesterol blood level; controlled study; enzyme activity; experimental study; fatty acid blood level; fermentation; glucose blood level; hyperglycemia; male; Monascus; nonhuman; pancreas; pancreas islet beta cell; priority journal; rat; streptozocin diabetes; triacylglycerol blood level; Wistar rat; yam; animal; blood; drug effect; enzymology; experimental diabetes mellitus; hypertriglyceridemia; metabolism; pancreas; pathology; Animals; Anti-Inflammatory Agents; Blood Glucose; Catalase; Cholesterol; Diabetes Mellitus, Experimental; Dioscorea; Fatty Acids, Nonesterified; Fermentation; Glutathione Reductase; Hypertriglyceridemia; Insulin; Interferon-gamma; Interleukin-1beta; Interleukin-6; Lipoproteins, LDL; Male; Monascus; Pancreas; Rats; Superoxide Dismutase; Triglycerides; Tumor Necrosis Factor-alpha
Type
journal article