An Adaptive Genomewide Scan Strategy in Linkage Analysis
Date Issued
2005
Date
2005
Author(s)
Chang, Hsiu-Hui
DOI
zh-TW
Abstract
Linkage analysis has been considered as a major instrument for gene mapping. When performing a genomewide scan, there requires a large number of markers being genotyped in advance and then being analyzed to find the candidate markers linked with the disease gene. To save the cost in labor and time, here we propose an adaptive stepwise selection strategy with the use of transmission/disequilibrium test that may only need to analyze a part of the whole markers to catch the disease gene. We have used computer simulation to investigate the efficiency of the adaptive genomewide scan strategy. In general, the results show that the strategy does not need to genotype all the markers and can still efficiently locate the gene.
Subjects
傳遞不平衡檢定
基因定位
效率
基因型判定
連鎖分析
transmission/disequilibrium test
gene mapping
efficiency
linkage analysis
genotyping
Type
thesis
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