Burkholderia cepacia bacteremia: A retrospective analysis of 70 episodes
Journal
Journal of the Formosan Medical Association
Journal Volume
96
Journal Issue
12
Pages
972-978
Date Issued
1997
Author(s)
Abstract
Burkholderia cepacia, a widespread gram-negative environmental bacillus associated with nosocomial infections, is considered to be of relatively low virulence and rarely to cause invasive disease. We retrospectively analyzed the risk factors, clinical manifestations, antimicrobial susceptibilities, and prognostic factors of B. cepacia bacteremia cases. From 1982 through 1995, 70 episodes of bacteremia due to B. cepacia occurred in 52 patients at the National Taiwan University Hospital. The overall case fatality rate was 11%. Sixty-four episodes were nosocomial infections. The common predisposing conditions were stay in an intensive care unit (61%) and invasive procedures, including urinary catheter (54%), intravenous catheter (70%), and intubation (57%). Three episodes involved polymicrobial bacteremia. In 41 episodes in which the infectious focus was identified, the respiratory tract was the most common portal of entry (17/41) followed by intravascular catheters (11/41). Most strains tested were susceptible to ceftazidime (95%), piperacillin (93%), minocycline (85%), and cefotaxime (82%); but most were resistant to aminoglycosides, tetracycline, carbenicillin, and ticarcillin. For empirical therapy of B. cepacia bacteremia, ceftazidime or piperacillin should be the drug of choice.
SDGs
Other Subjects
amikacin; aminoglycoside antibiotic agent; antibiotic agent; antineoplastic agent; aztreonam; beta lactam antibiotic; carbenicillin; cefoperazone; cefotaxime; ceftazidime; chloramphenicol; ciprofloxacin; corticosteroid; gentamicin; imipenem; latamoxef; minocycline; ofloxacin; piperacillin; tetracycline; ticarcillin; tobramycin; adolescent; adult; aged; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; article; bacteremia; burkholderia cepacia; cancer chemotherapy; catheter infection; catheterization; child; clinical feature; disease predisposition; female; hospital infection; human; immunosuppressive treatment; intensive care unit; intubation; major clinical study; male; microbiology; respiratory tract infection; risk factor; Adolescent; Adult; Aged; Bacteremia; Burkholderia cepacia; Burkholderia Infections; Child; Child, Preschool; Cross Infection; Female; Humans; Infant; Male; Middle Aged; Retrospective Studies
Type
journal article