Dyspnoea in a patient with hepatitis C
Journal
Heart
Journal Volume
102
Journal Issue
23
Date Issued
2016
Author(s)
Abstract
OBJECTIVE: Antithrombotic drugs are widely used in the prevention and treatment of cardiovascular diseases; yet, nationwide long-term usage trends remain unexplored. We examined long-term trends in the use of antithrombotic drugs in Denmark. METHODS: Using nationwide prescription data, we obtained information on primary care use of antiplatelet drugs, vitamin K antagonists (VKA), non-vitamin K antagonist oral anticoagulants (NOAC), heparins and fondaparinux during 1999-2014. RESULTS: During the 16-year period, the use of antithrombotic drugs per 1000 inhabitants/day increased from 64 to 96 defined daily doses (DDD), and the prevalence proportion of users doubled from 5.1% to 9.6% of the Danish population. From 1999 to 2014, there was an increased use of both antiplatelet drugs (from 60 to 79 DDD per 1000 inhabitants/day) and VKA (from 4 to 9 DDD per 1000 inhabitants/day). NOAC was marketed in 2008 and had an abrupt rise in use to 8 DDD per 1000 inhabitants/day in 2014. The use of heparins and fondaparinux increased slightly during the study period (from 0 to 0.6 DDD per 1000 inhabitants/day). Hospital use of antithrombotic drugs also increased during the study period, but constituted a minor part of the total use (4 DDD per 1000 inhabitants/day in 2014). CONCLUSIONS: Considerable changes have occurred in the use of antithrombotic drugs during the past 16 years, including the introduction of several new and increasingly used treatment modalities such as NOAC. The trends in use of individual drugs correlate well with the publication of landmark studies.
SDGs
Other Subjects
adult; case report; chronic hepatitis C; clinical feature; computer assisted tomography; contrast enhancement; disease exacerbation; dyspnea; electrocardiogram; human; hypoxemia; liver transplantation; male; middle aged; Note; pleura effusion; priority journal; sinus tachycardia; thorax radiography; transthoracic echocardiography; complication; diagnostic imaging; dyspnea; echocardiography; Hepatitis C, Chronic; hepatopulmonary syndrome; x-ray computed tomography; Dyspnea; Echocardiography; Hepatitis C, Chronic; Hepatopulmonary Syndrome; Humans; Liver Transplantation; Male; Middle Aged; Tomography, X-Ray Computed
Publisher
BMJ Publishing Group
Type
note