Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain
Journal
Lab on a Chip
Journal Volume
13
Journal Issue
6
Pages
1114-1120
Date Issued
2013
Author(s)
Abstract
Using a cell culture chip with a deformable substrate driven by a hydraulic force, we investigated the motility of cancer cells affected by myofibroblasts undergoing cyclic tensile strain (CTS). CTS reduced both the expression of α-smooth muscle actin in the myofibroblast and the ability of the myofibroblast to accelerate cancer cell migration. However, with the treatment of a pro-inflammatory factor interleukin-1β on the myofibroblasts, the effects of CTS on the myofibroblast were diminished. This result suggests an antagonism between mechanical and chemical stimulations on mediating cancer metastasis by the stromal myofibroblast. ? 2013 The Royal Society of Chemistry.
SDGs
Other Subjects
alpha smooth muscle actin; interleukin 1beta; article; cancer cell; cancer cell culture; cell interaction; cell migration; cell motility; controlled study; cyclic tensile strain; force; human; human cell; hydraulic conductivity; lung cancer; mechanical stimulation; metastasis; myofibroblast; priority journal; protein expression; stimulation; stroma cell; tensile strength
Publisher
Royal Society of Chemistry
Type
journal article