Two-pore channels: Catalyzers of endolysosomal transport and function
Journal
Frontiers in Pharmacology
Journal Volume
8
Journal Issue
FEB
Pages
45
Date Issued
2017
Author(s)
Abstract
and NAADP, and ATP has been found to block TPC activation via mTOR. Loss of TPCs can lead to obesity and hypercholesterolemia, and to a slow-down of intracellular virus and bacterial toxin trafficking, it can affect VEGF-induced neoangiogenesis, autophagy, human hair pigmentation or the acrosome reaction in sperm. Moreover, physiological roles of TPCs in cardiac myocytes and pancreatic β cells have been postulated.
SDGs
Type
review