Association between Cotinine and Metals in Maternal and Cord Blood in Non- Smoking Mothers
Resource
EPIDEMIOLOGY v.20 n.6 SUPPL. S pp.S167-S167
Journal
Epidemiology
Pages
S167
Date Issued
2009
Date
2009
Author(s)
WEN, TING-WEN
CHEN, PAU-CHUNG
Abstract
ISEE-0485 Background and Objective: Environmental tobacco smoke (ETS) contains over 4000 compounds, including numerous heavy and trace metals such as arsenic, lead, cadmium, and selenium. Smokers have been reported to have higher blood lead and cadmium levels than do nonsmokers. The objective of this study was to explore the association between cotinine and metals in maternal and umbilical cord blood in non-smoking mothers. Methods: The study population consisted of 328 postpartum women collected from four hospitals and clinics in northern Taiwan. We interviewed them by a structured questionnaire after delivery and collected maternal and umbilical cord blood at birth. Cotinine in blood as an indicator of ETS was analyzed by using HPLC-MS/MS and the metals were analyzed by Agilent 7500 C inductively coupled plasma mass spectrometry (ICP-MS). We examined the association between cotinine and log10 transformed metal levels by linear regression models. Result: After adjusting for maternal age and education, there were negative association between cadmium (β ± SE = –0.00005 ± 0.0011, P-value = 0.961), antimony (β ± SE = –0.00026 ± 0.0007, P-value = 0.689) and barium (β ± SE = –0.00414 ± 0.0025, P-value = 0.095) and cotinine in maternal blood. In umbilical cord blood, a negative association was found for antimony (β ± SE = –0.00113 ± 0.0005, P-value = 0.020) while positive associations were shown for thorium (β ± SE = 0.00237 ± 0.0011, P-value = 0.028) and uranium (β ± SE = 0.00307 ± 0.0015, P-value = 0.046). Conclusions: Although cotinine were associated with some metals in blood, environmental tobacco smoke may not be the major source of metals in the non-smoking population.
SDGs
Type
journal article