Changes in energy metabolites, cGMP and intracellular pH during cortical spreading depression
Journal
Brain Research
Journal Volume
641
Journal Issue
1
Pages
176-180
Date Issued
1994
Author(s)
Abstract
The spatial and temporal distribution of cerebral metabolites and pHi were examined in the cortex during spreading depression. Acidification and marked depression in the energy status of the tissue was evident at the wavefront of spreading depression. In its aftermath, the residual activation of glycolysis and accumulation of cGMP persisted for minutes after a relatively rapid restoration of high-energy phosphates and pHi.
SDGs
Type
journal article