Autologous Serum Eye Drops Combined with Silicone Hydrogen Lenses for the Treatment of Postinfectious Corneal Persistent Epithelial Defects
Journal
Eye and Contact Lens
Journal Volume
43
Journal Issue
4
Pages
225-229
Date Issued
2017
Author(s)
YAN-MING CHEN
Abstract
Objective: To evaluate the clinical effect of combined topical autologous serum eye drops (ASEs) and silicone hydrogel contact lens (CLs) for the treatment of corneal persistent epithelial defects (PEDs) after infectious corneal ulcers. Methods: We conducted a retrospective chart review of 12 patients with postinfectious corneal PEDs who were unsuccessfully treated with conventional medical management and were then treated with combined topical 20% (v/v) ASEs and silicone hydrogel CLs from July 1, 2011, to June 30, 2014. The corneal ulcers were all initially managed with antibiotic eye drops until the infiltrates resolved but the lesions failed to epithelialize. The clinical effects of the combined treatment were evaluated. Results: The PEDs healed in all 12 patients within 2 weeks. The combined treatment was associated with an improvement of best-corrected visual acuity (BCVA) at the final 3-month follow-up examination. All patients responded well to the combined treatment and no adverse events were noted in any patient. Conclusions: The combined use of silicone hydrogel CLs and ASEs can successfully treat postinfectious corneal PEDs and prevent continuous corneal melting during acute disease. ? 2016 Contact Lens Association of Ophthalmologists.
Subjects
Autologous serum; Corneal melting; Corneal ulcer; Post-infectious corneal persistent epithelial defect; Silicone-hydrogel contact lens
SDGs
Other Subjects
amikacin; artificial tear; autologous serum eye drop; cefazolin; eye drops; levofloxacin; moxifloxacin; unclassified drug; antiinfective agent; eye drops; hydrogel; silastic; adult; aged; antibiotic sensitivity; antibiotic therapy; Article; bacterial keratitis; bandage contact lens; best corrected visual acuity; chemosis; clinical article; conjunctival hyperemia; cornea disease; cornea epithelium; cornea ulcer; corneal persistent epithelial defect; eye pain; eye redness; female; follow up; human; male; medical record review; middle aged; pneumococcal infection; priority journal; Pseudomonas; Pseudomonas infection; silicone hydrogel contact len; Staphylococcus aureus; Staphylococcus infection; Streptococcus pneumoniae; treatment duration; treatment outcome; treatment response; visual acuity; case report; cornea epithelium; Corneal Ulcer; epithelization; Eye Infections, Bacterial; hydrogel; hydrophilic contact lens; microbiology; multimodality cancer therapy; pathology; retrospective study; serum; Adult; Aged; Anti-Bacterial Agents; Combined Modality Therapy; Contact Lenses, Hydrophilic; Corneal Ulcer; Epithelium, Corneal; Eye Infections, Bacterial; Female; Humans; Hydrogels; Male; Middle Aged; Ophthalmic Solutions; Re-Epithelialization; Retrospective Studies; Serum; Silicone Elastomers
Type
journal article