Hepatitis B: Immunization and Impact on Natural History and Cancer Incidence
Journal
Gastroenterology clinics of North America
Journal Volume
49
Journal Issue
2
Pages
201-214
Date Issued
2020
Author(s)
Lin C.-L.
Abstract
Enhancing host immunity by vaccination to prevent hepatitis B virus (HBV) infection remains the most important strategy for global control of hepatitis B. Currently, 187 countries have in place infant hepatitis B vaccination programs. Hepatitis B surface antigen prevalence has decreased to less than 1% in children after successful implementation of universal HBV vaccination in newborns. The incidence of primary liver cancer in children, adolescents, and young adults has drastically decreased to near zero in birth cohorts receiving hepatitis B vaccination. Elimination of chronic hepatitis B by 2030 is not a mission impossible. Copyright ? 2020 Elsevier Inc. All rights reserved.
Subjects
Hepatitis B vaccination; Hepatitis B virus; Hepatocellular carcinoma
SDGs
Other Subjects
biological marker; hepatitis B surface antigen; hepatitis B vaccine; adolescent; adult; blood; child; cohort analysis; complication; female; hepatitis B; human; incidence; infant; liver cell carcinoma; liver tumor; male; newborn; preschool child; prevalence; young adult; Adolescent; Adult; Biomarkers; Carcinoma, Hepatocellular; Child; Child, Preschool; Cohort Studies; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Incidence; Infant; Infant, Newborn; Liver Neoplasms; Male; Prevalence; Young Adult
Publisher
NLM (Medline)
Type
review