BST1 rs11724635 interacts with environmental factors to increase the risk of Parkinson's disease in a Taiwanese population
Journal
Parkinsonism and Related Disorders
Journal Volume
20
Journal Issue
3
Pages
280-283
Date Issued
2014
Author(s)
Abstract
A recently published genome-wide association study in Caucasian and Asian populations showed a significant association between the bone marrow stromal cell antigen 1 (BST1) SNP rs11724635 and increased risk for Parkinson's disease (PD). To investigate whether BST1 rs11724635 increases the risk of PD, either by itself or in combination with environmental factors, we performed an association analysis of BST1 rs11724635 in a large cohort of Taiwanese patients with PD and age matched controls. The study used TaqMan genotyping, logistic regression, and haplotype methods. The genotype distribution of rs11724635 in PD patients (N=468; p=0.50) and control subjects (N=487; p=0.44) was consistent with Hardy-Weinberg equilibrium. Compared with the AA genotype, the frequency of both CA and CC genotypes was not significantly different between the patient and control groups. The adjusted odd ratios (ORs) for CA and CC were not statistically significant (CA: OR=0.962, 95% CI=0.643-1.439, p=0.850; CC: OR=0.992, 95% CI=0.654-1.503, p=0.969). Of note, ever use of well water before the onset of PD symptoms had an impact on the occurrence of PD through interactions with BST1 rs11724635 AC (OR=1.453, p=0.024) and CC (OR=1.623, p=0.008). Our results show that the BST1 rs11724635 polymorphism alone is not associated with the development of PD, but it can interact with well water drinking to increase the risk of PD in this Taiwanese population. ? 2013 Elsevier Ltd.
SDGs
Other Subjects
bone marrow stromal cell antigen 1; stromal cell derived factor 1; unclassified drug; well water; adenosine diphosphate ribosyl cyclase; ADP-ribosyl cyclase 2; drinking water; glycosylphosphatidylinositol anchored protein; leukocyte antigen; adult; aged; article; BST1 gene; cohort analysis; controlled study; disease association; ethnicity; female; fluid intake; gene; gene frequency; genetic association; genetic risk; genotype; genotype environment interaction; haplotype; human; major clinical study; male; Parkinson disease; priority journal; risk assessment; single nucleotide polymorphism; Taiwan; Taiwanese; case control study; epidemiology; genetic polymorphism; genetic predisposition; genetics; middle aged; Parkinson disease; risk factor; ADP-ribosyl Cyclase; Aged; Antigens, CD; Case-Control Studies; Drinking Water; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; GPI-Linked Proteins; Humans; Male; Middle Aged; Parkinson Disease; Polymorphism, Genetic; Risk Factors; Taiwan
Publisher
Elsevier BV
Type
journal article