Effects of chitosan oligosaccharide on plasma and hepatic lipid metabolism and liver histomorphology in normal sprague-dawley rats
Journal
Marine Drugs
Journal Volume
18
Journal Issue
8
Date Issued
2020
Author(s)
Abstract
Chitosan oligosaccharide is known to ameliorate hypercholesterolemia and diabetes. However, some studies found that chitosan oligosaccharide might induce mild to moderate hepatic damage in high-fat (HF) diet-induced obese rats or diabetic rats. Chitosan oligosaccharide can be as a dietary supplement, functional food, or drug. Its possible toxic effects to normal subjects need to be clarified. This study is designed to investigate the effects of chitosan oligosaccharide on plasma and hepatic lipid metabolism and liver histomorphology in normal Sprague-Dawley rats. Diets supplemented with 5% chitosan oligosaccharide have been found to induce liver damage in HF diet-fed rats. We therefore selected 5% chitosan oligosaccharide as an experimental object. Rats were divided into: a normal control diet group and a normal control diet +5% chitosan oligosaccharide group. The experimental period was 12 weeks. The results showed that supplementation of 5% chitosan oligosaccharide did not significantly change the body weight, food intake, liver/adipose tissue weights, plasma lipids, hepatic lipids, plasma levels of AST, ALT, and TNF-α/IL-6, hepatic lipid peroxidation and anti-oxidative enzyme activities, fecal lipids, and liver histomorphology in normal rats. These findings suggest that supplementation of 5% chitosan oligosaccharide for 12 weeks may not induce lipid metabolism disorder and liver toxicity in normal rats. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Chitosan oligosaccharide; Lipid metabolism; Liver histomorphology; Normal rats
SDGs
Other Subjects
alanine aminotransferase; aspartate aminotransferase; chitosan oligosaccharide; feces lipid; interleukin 6; lipid; oligosaccharide; tumor necrosis factor; unclassified drug; autacoid; biological marker; chitin; enzyme; lipid; oligochitosan; adipose tissue; alanine aminotransferase blood level; animal experiment; animal model; animal tissue; Article; aspartate aminotransferase blood level; body weight; controlled study; diet supplementation; drug effect; enzyme activity; experimental design; food intake; lipid blood level; lipid diet; lipid liver level; lipid metabolism; lipid peroxidation; liver histology; liver injury; liver tissue; male; nonhuman; rat; Sprague Dawley rat; animal; blood; dietary supplement; drug effect; liver; metabolism; time factor; Animals; Biomarkers; Chitin; Dietary Supplements; Enzymes; Inflammation Mediators; Lipids; Liver; Rats, Sprague-Dawley; Time Factors
Publisher
MDPI AG
Type
journal article