A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test
Journal
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Journal Volume
2020-July
Pages
2438-2441
Date Issued
2020
Author(s)
Abstract
We have created a lung simulation to quantify lung heterogeneity from the results of the inspired sinewave test (IST). The IST is a lung function test that is non-invasive, non-ionising and does not require patients' cooperation. A tidal lung simulation is developed to assess this test and also a method is proposed to calculate lung heterogeneity from IST results. A sensitivity analysis based on the Morris method and linear regression were applied to verify and to validate the simulation. Additionally, simulated emphysema and pulmonary embolism conditions were created using the simulation to assess the ability of the IST to identify these conditions. Experimental data from five pigs (pre-injured vs injured) were used for validation. This paper contributes to the development of the IST. Firstly, our sensitivity analysis reveals that the IST is highly accurate with an underestimation of about 5% of the simulated values. Sensitivity analysis suggested that both instability in tidal volume and extreme expiratory flow coefficients during the test cause random errors in the IST results. Secondly, the ratios of IST results obtained at two tracer gas oscillation frequencies can identify lung heterogeneity (ELV60/ELV180 and Qp60/Qp180). There was dissimilarity between simulated emphysema and pulmonary embolism (p < 0.0001). In the animal model, the control group had ELV60/ELV180 = 0.58 compared with 0.39 in injured animals (p < 0.0001). ? 2020 IEEE.
Subjects
Diseases
Mammals
Random errors
Sensitivity analysis
Testing
Control groups
Expiratory flows
Highly accurate
Lung function
Morris method
Pulmonary embolism
Sine wave test
Tidal volume
Biological organs
animal
human
lung
lung function test
pig
tidal volume
Animals
Humans
Lung
Respiratory Function Tests
Swine
Tidal Volume
SDGs
Type
conference paper