Sofosbuvir-based Interferon-Free Direct Acting Antiviral Regimens for Heart Transplant Recipients with Chronic Hepatitis C Virus Infection
Journal
Clinical Infectious Diseases
Journal Volume
66
Journal Issue
2
Pages
289-292
Date Issued
2018
Abstract
We assessed the effectiveness and safety of sofosbuvir (SOF) combined with ledipasvir (LDV) or daclatasvir (DCV) in 12 heart transplant recipients with chronic hepatitis C virus (HCV). The sustained virologic response (SVR 12) rate was 100% [95% confidence interval [CI]: 75.8%-100%]. All patients tolerated treatment well without interruption, death, or serious adverse events. ? The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
SDGs
Other Subjects
alanine aminotransferase; cyclosporine; daclatasvir; everolimus; ledipasvir plus sofosbuvir; mycophenolate mofetil; prednisone; rapamycin; sofosbuvir; tacrolimus; virus RNA; antivirus agent; benzimidazole derivative; BMS-790052; fluorene derivative; imidazole derivative; ledipasvir; sofosbuvir; adult; alanine aminotransferase blood level; anemia; Article; chronic hepatitis C; clinical article; clinical assessment; confidence interval; drug dose titration; drug efficacy; drug safety; drug tolerability; duodenal ulcer bleeding; endoscopic therapy; female; graft recipient; heart transplantation; human; male; middle aged; priority journal; sustained virologic response; treatment outcome; adverse drug reaction; adverse event; chronic hepatitis C; combination drug therapy; pathology; procedures; prospective study; young adult; Adult; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Fluorenes; Heart Transplantation; Hepatitis C, Chronic; Humans; Imidazoles; Male; Middle Aged; Prospective Studies; Sofosbuvir; Sustained Virologic Response; Transplant Recipients; Treatment Outcome; Young Adult
Publisher
Oxford University Press
Type
journal article