Anti-herpes simplex virus activity of Bidens pilosa and Houttuynia cordata
Journal
American Journal of Chinese Medicine
Journal Volume
31
Journal Volume
31
Journal Issue
3
Journal Issue
3
Pages
355-362
Start Page
355
End Page
362
ISSN
0192415X
Date Issued
2003
Author(s)
Abstract
The present study evaluated the antiviral activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb., using cytotoxicity test with XTT-based colorimetric assay. BCC-1/KMC cells were infected with herpes simplex virus (HSV) and then were cultured with hot water extract of B. pilosa (HWBP) or H. cordata (HWHC). Results showed that HWBP significantly inhibited the replication of HSV at a concentration of 100 pg/ml (11.9% for HSV-1, p < 0.01; 19.2% for HSV-2, p < 0.005), whereas HWHC had the same effect at a concentration of 250 μg/ml (10.2% for HSV-1, p < 0.05; 32.9% for HSV-2, p < 0.005). The ED50 of HSV type 1 (HSV-1) and HSV type 2 (HSV-2) for HWBP was 655.4 μg/ml and 960 μg/ml respectively, for HWHC it was 822.4 μg/ml and 362.5 μg/ml respectively. Both drugs had selective indexes above 1.04. H. cordata had better effect against HSV-2 than HSV-1, and had a low ED50 against HSV-2. We suggest that H. cordata might be a useful medicinal plant against infection of HSV-2.
Subjects
Bidens pilosa
Herpes Simplex Virus
Houttuynia cordata
SDGs
Type
journal article