Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study
Journal
Metabolism: Clinical and Experimental
Journal Volume
61
Journal Issue
12
Pages
1747-1755
Date Issued
2012
Author(s)
Yang T.
Chu C.-H.
Bai C.-H.
You S.-L.
Chou Y.-C.
Hwang L.-C.
Sun C.-A.
Abstract
Objective: Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort. Methods: Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n= 3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension. Results: During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend.004) for BPP and 1.68 (1.23-2.04, P for trend.028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity. Conclusion: We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population. ? 2012 Elsevier Inc.
SDGs
Other Subjects
creatinine; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; uric acid; abdominal obesity; adult; article; body mass; cholesterol blood level; creatinine blood level; disease course; female; follow up; glomerulus filtration rate; glucose blood level; human; hypertension; incidence; major clinical study; male; priority journal; risk factor; triacylglycerol blood level; uric acid blood level; waist circumference; Adult; Asian Continental Ancestry Group; Biological Markers; Blood Pressure; Cohort Studies; Disease Progression; Female; Humans; Hypertension; Incidence; Male; Middle Aged; Obesity, Abdominal; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Taiwan; Uric Acid
Type
journal article