Positive Immuno-Modulation Following Radiofrequency Assisted Liver Resection in Hepatocellular Carcinoma
Journal
Journal of clinical medicine
Journal Volume
8
Journal Issue
3
Date Issued
2019-03-19
Author(s)
Jayant, Kumar
Yang, Po-Chih
Habib, Nagy
Sodergren, Mikael H
Abstract
Hepatocellular carcinoma (HCC) often develops on a background of chronic inflammation and a complex immunosuppressive network with increased regulatory T cells, impaired CD8⁺ T cells and the secretion of immunosuppressive cytokines. Previous clinical studies have reported a superior disease-free survival (DFS) following a radiofrequency-based ablation or resection in HCC tumours compared to conventional liver resection techniques. The aim of this study was to investigate whether there is any correlation with the use of a radiofrequency-assisted liver resection and clinical outcome.
Subjects
liver cancer; liver resection; radiofrequency based device
Liver cancer; Liver resection; Radiofrequency based device
SDGs
Other Subjects
gamma interferon; interleukin 17; interleukin 1beta; interleukin 6; tumor necrosis factor; Article; blood; cancer surgery; CD4+ T lymphocyte; CD8+ T lymphocyte; cell composition; chronic inflammation; clinical outcome; disease free survival; enzyme linked immunosorbent assay; flow cytometry; histopathology; immune deficiency; immune response; immunocompetent cell; immunological parameters; immunomodulation; immunosuppressive treatment; inflammation; liver cell carcinoma; liver resection; radiofrequency; regulatory T lymphocyte; tumor growth; tumor microenvironment; tumor volume
Type
journal article