Histiocytoid Sweet's Syndrome During Induction Therapy with All-trans Retinole Acid for Acute Promyelocytic Leukemia: A Case Report
Journal
Journal of Internal Medicine of Taiwan
Journal Volume
32
Journal Issue
3
Date Issued
2021-06-01
Author(s)
CHO, SHENG LI
Abstract
Histiocytoid Sweet's syndrome is a recently described histopathologic variant of Sweet's syndrome. This is the first case report describing histiocytoid variant of Sweet's syndrome caused by all-trans retinole acid in a patient with acute promyelocytic leukemia. We present a 30-year-old man with newly diagnosed acute promyelocytic leukemia who received induction chemotherapy containing all-trans retinole acid and developed fever and painful erythematous cutaneous papules on day 13 of therapy. A diagnosis of histiocytoid Sweet's syndrome was made. All-trans retinoic acid was considered the culprit drug to induce this event. Treatment with corticosteroids Improved the systemic and cutaneous signs. A literature search identified only 17 eases of Sweet's syndrome during all-trans retinoic acid therapy, but none were of the histiocytoid variant. The presented clinical course resembles previously reported cases of Sweet's syndrome. This case emphasizes the rare effect of all-trans retinoic acid therapy causing histiocytoid Sweet's syndrome manifesting as fever and skin papules.
Subjects
Acute promyelocytic leukemia | Case report | Drug-related side effects | Retinoic acid | Sweet's syndrome
SDGs
Type
journal article