Gut Bifidobacterium longum is associated with better native liver survival in patients with biliary atresia
Journal
JHEP Reports
Journal Volume
6
Journal Issue
7
Start Page
Article 101090
ISSN
2589-5559
Date Issued
2024-07
Author(s)
Chee-Seng Lee
Chia-Ray Lin
Huey-Huey Chua
Abstract
Background & Aims: The gut microbiome plays an important role in liver diseases, but its specific impact on biliary atresia (BA) remains to be explored. We aimed to investigate the microbial signature in the early life of patients with BA and to analyze its influence on long-term outcomes. Methods: Fecal samples (n = 42) were collected from infants with BA before and after Kasai portoenterostomy (KPE). The stool microbiota was analyzed using 16S rRNA next-generation sequencing and compared with that of age-matched healthy controls (HCs). Shotgun metagenomic sequencing analysis was employed to confirm the bacterial composition in 10 fecal samples before KPE. The correlation of the microbiome signature with liver function and long-term outcomes was assessed. Results: had reduced total and direct bilirubin after KPE. Conclusion: in early infancy correlating with better long-term outcomes. Impact and implications: levels in the gut could be a therapeutic strategy to improve the prognosis of patients with biliary atresia.
SDGs
Publisher
Elsevier BV
Type
journal article