Development of bacterial transglycosylase inhibitors as new antibiotics: Moenomycin A treatment for drug-resistant Helicobacter pylori
Journal
Bioorganic and Medicinal Chemistry Letters
Journal Volume
24
Journal Issue
11
Pages
2412-2414
Date Issued
2014
Author(s)
Abstract
The problem of multidrug-resistant Helicobacter pylori requires new antibiotics development. We have evaluated a potential antibiotics, moenomycin A, which is classified as a phosphoglycolipid antibiotics that targets transglycosylase and is previously thought to be limited in Gram-positive bacteria. Herein, we report the activity of moenomycin A against multidrug-resistant H. pylori and the isolates from patients with different gastrointestinal diseases.
SDGs
Publisher
Elsevier Ltd
Type
journal article