Sleep Duration and Proteinuria Progression: A Population-Based Cohort Study
Journal
American Journal of Nephrology
Journal Volume
49
Journal Issue
1
Pages
41-51
Date Issued
2019
Author(s)
Abstract
Background: Extensive studies have demonstrated that sleep is an important modulator of cardiovascular and metabolic diseases. However, its impact on renal function remains uncertain. Methods: A total of 26,249 adults aged ?20 years were recruited through voluntary health examinations in Taiwan. Sleep duration was self-reported by questionnaire. Proteinuria was graded semi-quantitatively by dipstick urine test. The associations of sleep duration with proteinuria and estimated glomerular filtration rate (eGFR) were analyzed. Results: After an average follow-up period of 2.62 years, the crude hazard ratio (HR) for proteinuria progression were 1.92 (95% CI 1.22-3.03), 1.23 (95% CI 1.09-1.39), and 1.18 (95% CI 1.00-1.39) for those with sleep duration < 4, 4-6, and > 8 h compared to those with sleep duration of 6-8 h (the reference group), respectively. The HR remained significant for those with sleep duration < 4 h (adjusted HR 1.65 [95% CI 1.05-2.61]) and 4-6 h (adjusted HR 1.19 [95% CI 1.06-1.35]) after adjustment for age, sex, blood pressure, fasting glucose, body mass index, cholesterols, triglycerides, uric acids, physical activity, smoking, alcohol consumption, income/educational levels, and baseline eGFR. However, eGFR was not significantly different among different sleep duration groups. Discussion: This result indicates short sleep duration is independently associated with the progression of proteinuria. ? 2018 S. Karger AG, Basel.
Other Subjects
cholesterol; creatinine; glucose; high density lipoprotein cholesterol; triacylglycerol; uric acid; adult; age; alcohol consumption; Article; body mass; cohort analysis; comorbidity; cross-sectional study; diastolic blood pressure; disease exacerbation; dysglycemia; educational status; estimated glomerular filtration rate; female; follow up; human; hypercholesterolemia; hypertension; hypertriglyceridemia; hyperuricemia; income; kidney function; lifestyle; major clinical study; male; mean arterial pressure; medical examination; obesity; physical activity; polysomnography; priority journal; proteinuria; questionnaire; sensitivity analysis; sleep quality; sleep time; smoking; social status; systolic blood pressure; urinalysis; disease exacerbation; glomerulus filtration rate; middle aged; pathophysiology; physiology; proteinuria; self report; sleep; Taiwan; time factor; urine; young adult; Adult; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Male; Middle Aged; Proteinuria; Self Report; Sleep; Taiwan; Time Factors; Young Adult
Publisher
S. Karger AG
Type
journal article