Vascular Morphology and Tortuosity Analysis of Breast Tumor Inside and Outside Contour by 3-D Power Doppler Ultrasound
Journal
Ultrasound in Medicine and Biology
Journal Volume
38
Journal Issue
11
Pages
1859-1869
Date Issued
2012
Author(s)
Abstract
This study aimed to evaluate morphologic and tortuous features of vessels inside and outside the tumor region on three-dimensional power Doppler ultrasonography (PDUS) in 113 breast mass lesions, including 60 benign and 53 malignant tumors. Compared with benign lesions, malignant breast lesions had significantly larger values of vascular morphologic and tortuous features and larger tumor sizes. The receiver operating characteristic curve analysis and Student's t-test were used to estimate the performance of a proposed classification system using 13 vascular features and tumor size selected by the neural network. Accuracy, sensitivity, specificity, positive predictive value, negative predictive value and the AZ value of the diagnosis performance based on 14 features were 89.38% (101/113), 84.91% (45/53), 93.33% (56/60), 91.84% (45/49), 87.50% (56/64) and 0.9188, respectively. The three-dimensional PDUS morphologic and tortuous characteristics of blood vessels inside and outside breast mass lesions can be effectively used to classify benign and malignant tumors. ? 2012 World Federation for Ultrasound in Medicine & Biology.
SDGs
Other Subjects
3-D ultrasound; Benign and malignant tumors; Benign lesion; Breast lesion; Breast mass; Breast tumor; Classification system; Diagnosis performance; Malignant tumors; Negative predictive value; Positive predictive values; Power Doppler; Power doppler ultrasonographies; Receiver operating characteristic curve analysis; Tortuosity; Tumor size; Vascularity; Blood vessels; Morphology; Statistical tests; Three dimensional; Tumors; Ultrasonography; Diagnosis; article; artificial neural network; breast cancer; breast tumor; cancer classification; cancer morphology; controlled study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; differential diagnosis; Doppler flowmetry; histopathology; human; human tissue; image processing; major clinical study; needle biopsy; predictive value; priority journal; receiver operating characteristic; sensitivity and specificity; three dimensional power Doppler ultrasound; tumor volume; ultrasound scanner; Adult; Aged; Algorithms; Breast Neoplasms; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Middle Aged; Neovascularization, Pathologic; Reproducibility of Results; Sensitivity and Specificity; Ultrasonography, Doppler, Pulsed; Ultrasonography, Mammary
Type
journal article