食物砷之攝取對職業性砷暴露評估之影響
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
DOI
912320B002173
Abstract
The present study was conducted to
explore the potential confounding effects
resulting from dietary arsenic intake from
seafoods with the aims to delineate the
effects of seafood items and time since
seafood ingestion on the elevation of
speciated urinary arsenic metabolite levels.
Among the ten seafoods determined for
arsenic species, the most common arsenic
species was arsenobetaine, with the highest
total arsenic content found in flower crab,
219.42 ug/g and the lowest observed in
seasand shrimp, 2.58 ug/g. Twelve volunteers
were invited to participate in the next step
seafood-restrain study. The seafoods used for
this study included brown seaweed, clam,
oyster, and shrimp from the ten
aforementioned seafoods. During the
one-week study period, study subjects were
provided with all meals for dietary control
and restrained from any aquatic and seafoods,
except the designated study seafoods
aforementioned provided in the lunch meal
and dinner meal on the fourth day. All the
urine excretions of the study subjects were
separately collected in 500 ml bottles for the
day prior to seafood ingestion, and the
following 3 consecutive days. Urinary arsenic
metabolites were determined with high
performance liquid chromatography - hydride
generation - atomic absorption spectrometry,
including arsenite(As 3+ ), arsenate (As 5+ ), monomethylarsonic acid (MMA) and
dimethylarsinic acid (DMA). DMA
dominated the urinary arsenic metabolites,
constituting about 80 % of the total arsenicals
excreted. Average DMA concentrations in
the first morning void samples after ingestion
of the brown seaweeds, clam, oyster were
36.4±7.8 ug/L, 48.6±15.1 ug/L, 26.6±5.2
ug/L, respectively. In general, an elevation
of urinary arsenic levels by 30 ug/L is
possible by regular meals composed of 150 g
seafoods, implying a critical confounding
effect of seafood ingestion on the biological
marker for inorganic arsenic exposure
monitoring. The findings of the present study
also shed light on the significant individual
variation in the arsenic metabolism and/or
the capability of arsenic detoxification.
Further studies emphasizing on the individual
susceptibility to arsenic exposure are
warranted in order to explore the
comprehensive effects of seafood intake on
the distribution of urinary arsenic species,
and even more on the arseniasis.
Subjects
seafood
urine
arsenic
speciation
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
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