New Bioactive Clerodane Diterpenoids from the Roots of Casearia membranacea
Resource
Chemistry & Biodiversity v.5 n.1 pp.162-167
Journal
Chemistry & Biodiversity
Journal Volume
v.5
Journal Issue
n.1
Pages
162-167
Date Issued
2008
Date
2008
Author(s)
Chen, Ching-Yu
Cheng, Yuan-Bin
Chen, Shun-Ying
Chien, Ching-Te
Kuo, Yao-Haur
Guh, Jih-Hwa
Khalil, Ashraf Taha
Shen, Ya-Ching
Abstract
Bioassay-guided fractionation of the acetone extract of the roots of Casearia membranacea furnished three new clerodane diterpenes, caseamembrins S-U (1-3) and the known caseamembrin Q (4). Their structures were established by extensive spectroscopic analyses, especially 2D-NMR. Compounds 1-4 were tested against human tumor cells, including HeLa ( cervical epitheloid carcinoma), DLD-1 (colon carcinoma), Daoy ( medulloblastoma), and KB (oral epidermoid carcinoma) cell lines. Caseamembrin T (2) exhibited the most potent activity against Daoy cells ( ED50 = 10 ng/ml), superior to that of the standard drug mitomycin.
File(s)![Thumbnail Image]()
Loading...
Name
145.pdf
Size
172.98 KB
Format
Adobe PDF
Checksum
(MD5):aca51a12d3b34d246e89f154a7e1c1bf