Design and Synthesis of Activity Probes for Glycosidases
Resource
Organic Letters 4 (21): 3607-3610
Journal
Organic Letters
Journal Volume
4
Journal Issue
21
Pages
3607-3610
Date Issued
2002
Date
2002
Author(s)
Abstract
[structure: see text] A new synthetic route was developed for the preparation of activity probe 1 for beta-glucosidase in this study. The key glycosidation step begins with benzyl p-hydroxyphenylacetate. Benzylic functionalization for the construction of the trapping device was achieved at later stages. Probe 1 was shown to be able to label the target enzyme. This cassette-like design offers great flexibility for future alterations. It would allow the synthetic scheme to expand to other glycosidase probes with different linker/reporter combinations.
Type
journal article
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