Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure
Journal
PLoS ONE
Journal Volume
7
Journal Issue
4
Date Issued
2012
Author(s)
Huang Y.-T.
Chiang L.-T.
Huang S.-W.
Tseng C.-D.
Chen Y.-H.
Abstract
Objective: Myosin binding protein C (MYBPC3) plays a role in ventricular relaxation. The aim of the study was to investigate the association between cardiac myosin binding protein C (MYBPC3) gene polymorphisms and diastolic heart failure (DHF) in a human case-control study. Methods: A total of 352 participants of 1752 consecutive patients from the National Taiwan University Hospital and its affiliated hospital were enrolled. 176 patients diagnosed with DHF confirmed by echocardiography were recruited. Controls were matched 1-to-1 by age, sex, hypertension, diabetes, renal function and medication use. We genotyped 12 single nucleotide polymorphisms (SNPs) according to HapMap Han Chinese Beijing databank across a 40 kb genetic region containing the MYBPC3 gene and the neighboring DNA sequences to capture 100% of haplotype variance in all SNPs with minor allele frequencies ?5%. We also analyzed associations of these tagging SNPs and haplotypes with DHF and linkage disequilibrium (LD) structure of the MYBPC3 gene. Results: In a single locus analysis, SNP rs2290149 was associated with DHF (allele-specific p = 0.004; permuted p = 0.031). The SNP with a minor allele frequency of 9.4%, had an odds ratio 2.14 (95% CI 1.25-3.66; p = 0.004) for the additive model and 2.06 for the autosomal dominant model (GG+GA: AA, 95% CI 1.17-3.63; p = 0.013), corresponding to a population attributable risk fraction of 12.02%. The haplotypes in a LD block of rs2290149 (C-C-G-C) was also significantly associated with DHF (odds ratio 2.10 (1.53-2.89); permuted p = 0.029). Conclusions: We identified a SNP (rs2290149) among the tagging SNP set that was significantly associated with early DHF in a Chinese population. ? 2012 Wu et al.
SDGs
Other Subjects
myosin binding protein C; adult; allele; article; autosomal dominant disorder; case control study; Chinese; controlled study; diabetes mellitus; diastolic heart failure; DNA sequence; echocardiography; female; gene; gene deletion; gene frequency; gene linkage disequilibrium; gene locus; gene structure; genetic association; genetic polymorphism; genetic risk; genotype; haplotype map; human; hypertension; kidney function; major clinical study; male; MYBPC3 gene; pathogenesis; promoter region; single nucleotide polymorphism; treatment indication; Aged; Carrier Proteins; Case-Control Studies; Death Domain Receptor Signaling Adaptor Proteins; Echocardiography; Female; Gene Deletion; Gene Frequency; Genetic Predisposition to Disease; Guanine Nucleotide Exchange Factors; Haplotypes; Heart Failure, Diastolic; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide
Type
journal article