URINARY ARSENIC SPECIATION IN SUBJECTS WITH OR WITHOUT RESTRICTION FROM SEAFOOD DIETARY INTAKE
Resource
TOXICOLOGY LETTERS v.133 n.1 pp.83-91
Journal
TOXICOLOGY LETTERS
Journal Volume
v.133
Journal Issue
n.1
Pages
83-91
Date Issued
2002
Date
2002
Author(s)
CHEN, CHIEN-JEN
Abstract
In order to understand whether ingestion of seafood affects the urinary arsenic metabolites. About 42 women and 36 men were recruited from the students, parents and teachers in Taipei Medical University and National Taiwan University. The study subjects were interviewed about dietary habits, cigarette smoking habits, drug and vitamin intake, and consumption of seafood. Urine samples were collected from study subjects before and after refraining from eating seafood for 3 days, respectively. The urine samples were frozen at -20 degreesC separated by high-performance liquid chromatography (HPLC), and on line linked to hydride generator atomic absorption spectrometry (HGAAS) to quantify the levels of various species of inorganic arsenic and its metabolites. The levels of arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), total inorganic arsenic metabolites, inorganic arsenic percent, MMA,percent and DMA percent were similar before and after refraining from eating seafood for 3 days. The frequencies of fish, shellfish and seaweed dietary intake were not significantly correlated with urinary arsenic species. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Subjects
arsenic
urinary arsenic speciation
seafood
dietary habits
DRINKING-WATER
METHYLATION
Type
journal article