Clinical burden of autosomal dominant polycystic kidney disease
Journal
Aging
Journal Volume
12
Journal Issue
4
Pages
3899-3910
Date Issued
2020
Author(s)
Abstract
There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individually selected patients with and without ADPKD from inpatient data files as well as from the catastrophic illness registry in Taiwan based on 1:5 frequency matching for sex, age, and index year. The hazard ratios (HR) of all-cause mortality, ischemic stroke, hemorrhagic stroke and end-stage renal disease (ESRD) in ADPKD inpatients were elevated as compared to the controls. Similarly, ADPKD patients from the catastrophic illness registry had an increased risk of hemorrhagic stroke and ESRD. Allopurinol users also had an increased risk of all-cause mortality. The HR for developing ESRD after medication exposure was 0.47-fold for statin and 1.93-fold for pentoxifylline. These results reveal that patients with ADPKD (either inpatient or from the catastrophic illness registry) are at elevated risk for hemorrhagic stroke and ESRD, and suggest that allopurinol and pentoxifylline should not be prescribed to ADPKD patients due to possible adverse effects. ? Hung et al.
Subjects
All-cause mortality; Autosomal dominant polycystic kidney disease; End-stage renal disease; Hemorrhagic stroke; Time-dependent cox proportional hazard regression
SDGs
Other Subjects
adult; aged; brain hemorrhage; brain ischemia; chronic kidney failure; complication; disease exacerbation; female; human; kidney polycystic disease; male; middle aged; mortality; register; risk factor; Taiwan; young adult; Adult; Aged; Disease Progression; Female; Hemorrhagic Stroke; Humans; Ischemic Stroke; Kidney Failure, Chronic; Male; Middle Aged; Polycystic Kidney, Autosomal Dominant; Registries; Risk Factors; Taiwan; Young Adult
Publisher
Impact Journals LLC
Type
journal article