Cerebellar α 6 -subunit-containing GABA A receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders
Journal
British Journal of Pharmacology
Journal Volume
175
Journal Issue
12
Pages
2414-2427
Date Issued
2018
Author(s)
Lee H.-J.
Ernst M.
Huang W.-J.
Chou J.-F.
Chen H.-L.
Mouri A.
Chen L.-C.
Treven M.
Mamiya T.
Knutson D.E.
Witzigmann C.
Cook J.
Sieghart W.
Nabeshima T.
Abstract
BACKGROUND AND PURPOSE: receptors in disrupted prepulse inhibition of the startle response (PPI), which reflects sensorimotor gating deficits manifested in several neuropsychiatric disorders. EXPERIMENTAL APPROACH: receptors. KEY RESULTS: receptor-mediated GABA currents. CONCLUSIONS AND IMPLICATIONS: receptor-selective PAMs are potential medicines for treating sensorimotor gating deficits in neuropsychiatric disorders. A mechanistic hypothesis is based on evidence for cerebellar contributions to cognitive functioning including sensorimotor gating.
SDGs
Type
journal article