Soluble inflammatory markers in coronary sinus and peripheral blood of heart transplant recipients
Journal
Clinical Transplantation
Journal Volume
17
Journal Issue
4
Pages
331-337
Date Issued
2003
Author(s)
Abstract
Cardiac allograft rejection is a focal inflammation and soluble markers are released into coronary sinus (CS). We investigated whether plasma-soluble markers in CS is better to predict the clinical status of transplant recipients than in peripheral blood (PB). Between February 1998 and January 2001, 51 patients admitted for endomyocardial biopsy were included. The clinical events of the transplant recipient were recorded as: early post-transplant, long-term uneventful status, infection, acute rejection and transplant coronary artery disease. The plasma levels of interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α), ICAM-1, P-selectin, high-sensitive C-reactive protein (CRP) and troponin-I of CS and PB were determined. There were 71 blood samples. In patients within 1 month after heart transplant, there was a higher level of P-selectin, ICAM-1, CRP and troponin-I in CS and PB. In patients with infection, there was a higher level of all soluble markers except IL-2 in CS and PB. Patients with a long-term uneventful status had a lower level of CRP in PB but not in CS. Patients with acute rejection had a higher level of IL-2 in PB but not in CS. Patients with transplant coronary artery disease had a higher level of TNF-α in PB but not in CS. Soluble markers in CS failed to predict the occurrence of acute or chronic rejections.
SDGs
Other Subjects
biological marker; C reactive protein; cytokine; intercellular adhesion molecule 1; interleukin 2; PADGEM protein; troponin I; tumor necrosis factor alpha; acute graft rejection; adult; aged; article; blood; blood level; blood sampling; chronic graft rejection; controlled study; coronary artery disease; coronary sinus; female; graft rejection; heart graft; heart muscle biopsy; heart transplantation; hospital admission; human; infection; inflammation; major clinical study; male; postoperative period; prediction; priority journal; recipient; Biological Markers; C-Reactive Protein; Case-Control Studies; Cell Adhesion Molecules; Cross-Sectional Studies; Cytokines; Female; Graft Rejection; Heart Transplantation; Humans; Infection; Inflammation; Male; Middle Aged; Time Factors; Troponin I
Type
journal article