Electrospun Nanofibers Containing photosensitive polymer for hyperthermia in Cancer Therapy
Date Issued
2014
Date
2014
Author(s)
Lin, Wei-Ting
Abstract
Hyperthermia, the heating of cancerous tissues to between 41 and 45 oC, has
been shown to improve the efficacy of cancer therapy when used in conjunction with
irradiation and/or chemotherapy. The objective of this study was to develop an
incorporation of electrospun sheet with photosensitizer for photodynamic therapy in
surface cancer tumor, such as skin cancer. The blend of poly-L-lactic acid (PLLA)
and chlorophyllin sodium copper (CSC) was electrospinning a sheet was developed.
The electrospun sheets could be remotely heated upon exposure to an external wave
length 532 nm green laser to kill cells.
In the second part of the study, for the purpose to produce high percentage
chlorophyllin sodium copper contain polystyrene , we used chlorophyllin sodium
copper and styrene with ATRP, and electrospinning to sheet for the hyperthermia
purpose. Then we used MTT assay、trypan blue stain and live/dead stain to observe
the effect of green laser intensity and irradiation time to the cell viability. Finally we
can achieve the purpose of killing cancer cell by control the green laser intensity and
irradiation time without hurting the normal cell around. We can use this result on the
hyperthermia of in surface cancer tumor, such as skin cancer.
Subjects
電訪絲
光熱療法
綠光雷射
SDGs
Type
thesis
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