Risk Assessment of human arsenic species exposure through consumption of farmed fish/bivalves in blackfoot disease area
Date Issued
2004
Date
2004
Author(s)
Huang, Feng-Mei
DOI
zh-TW
Abstract
This study estimated the human health risk of ingesting farmed fish, oyster and clam in blackfoot disease area of Taiwan. Field samples were collected including aquacultural pond water, fish and shellfish (tilapia Oreochromis mossambica, oyster Crassostrea gigas and clam Meretrix lusoria). Concentrations of arsenic (As) species, included total As（AST）, As(V), As(III), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were analyzed. The analytical result reveals that the ratio of inorganic As（ASi） to AST is 72.6~88.1% in the aquacultural ponds, and the H2AsO3-form of As(III) and the H2AsO4- form of As(V) predominate species for ASi. However, the ASi/ AST ratio in tilapia is 5.6~12.8%. The As(III) concentrations in tilapia range from 0.017 to 0.047μg/g, and the As(V) concentrations in tilapia range from 0.015to 0.048μg/g. The ASi/ AST ratio in oyster is approximately 1.64%. The As(III) concentrations in oyster range from 0.071 to 0.145μg/g, and the As(V) concentrations in oyster range from 0.032 to 0.068μg/g. The ASi/ AST ratio in clam is approximately 10.9%. The As(III) concentrations in clam range from 0.19to 1.671μg/g, and the As(V) concentrations in clam range from 0 to 0.13μg/g.
An oral carcinogenic potency slope (CPSo) of 1.5 (mg/kg/day)-1 for ASi was used to assess the human carcinogenic risk of ingesting fish, oyster and clam under ingestion rates of 10-70, 18.6-56 and 5-14.5 g/day. The estimated target cancer risks (TR) based on a 95% occurrence probability range from 3.54x10-6 to 3.54x10-5, 1.26x10-5 to 3.82x10-5, and 1.28x10-5 to 2.96x10-5 for fish, oyster and clam, respectively.
Owing to the different toxicity of As (III) and As(V), the CPSo of 1.95 and 0.39(mg/kg/day)-1 for As(III) and As(V), respectively, were proposed to assess the carcinogenic risk of ingesting fish, oyster and clam under the ingestion rates of 10-70, 18.6-56 and 5-14.5 g/day. The TR values based on a 95% exposure occurrence probability range from 2.95x10-6 to 2.06x10-5, 1.24x10-5 to 3.73x10-5, and 1.25x10-5 to 3.08x10-5 for fish, oyster and clam, respectively.
A target hazard quotient (THQ) was used to assess the noncarcinogenic risk of ingesting fish, oyster and clam with inorganic As under the ingestion rates of 10-70, 18.6-56 and 5-14.5 g/day. The THQ values based on a 95% exposure occurrence probability range from 0.019 to 0.138, 0.071 to 0.214 and 0.057 to 0.166, respectively, for the three ingestion rates. All THQ values are below one within the safe for human health.
The estimated TR values of using the CPSo of 2 and 0.4 (mg/kg/day)-1 for As(III) and As(V), respectively, are either larger than those of using the CPSo of 1.5 (mg/kg/day)-1 for inorganic As. Because of smaller no definite relationship were found on the proportion of As(III)and As(V)in fish and shellfish, using the CPSo of 1.95 and 00.39(mg/kg/day)-1 for As(III)and As(V), respectively, are recommended to accurately estimate the carcinogenic risk of inorganic As by consumption of farmed fish/shellfish in blackfoot disease area.
Subjects
吳郭魚
牡蠣
物種砷
健康風險評估
Tilapia
Oyster
Clam
Arsenic species
Health risk analysis
SDGs
Type
thesis
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