Durumolides A-E, anti-inflammatory and antibacterial cembranolides from the soft coral Lobophytum durum
Journal
Tetrahedron
Journal Volume
64
Journal Issue
41
Pages
9698-9704
Date Issued
2008
Author(s)
Abstract
Chemical investigations on the acetone extract of the soft coral Lobophytum durum have afforded five new cembranoids with a trans-fused α-methylene-γ-lactone, durumolides A-E (1, 6, and 8-10), and five previously characterized cembrane-based diterpenoids (2-5 and 7). The structures of the isolated metabolites were elucidated through extensive spectroscopic analyses, while the relative stereochemistry of 4 was confirmed by X-ray diffraction analyses. Moreover, the absolute configurations of 3-5 and 8 were established by application of modified Mosher's method. The anti-inflammatory effects, antibacterial activities, and inhibition assay of HCMV (Human cytomegalovirus) endonuclease activity of these isolated metabolites 1-10 were evaluated in vitro. © 2008 Elsevier Ltd. All rights reserved.
SDGs
Type
journal article