Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta
Journal
Marine Drugs
Journal Volume
12
Journal Issue
5
Pages
2446-2457
Date Issued
2014
Author(s)
Abstract
New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. ? 2014 by the authors licensee MDPI.
Subjects
Anti-inflammatory activity; Cladiella hirsuta; Cytotoxic activity; Eunicellins; Soft coral
Other Subjects
2 morpholino 8 phenylchromone; diterpenoid; elastase; hirsutalin N; hirsutalin O; hirsutalin P; hirsutalin Q; hirsutalin R; placebo; superoxide; unclassified drug; antineoplastic agent; diterpene; eunicellin; nonsteroid antiinflammatory agent; animal tissue; antiinflammatory activity; article; cancer cell; Cladiella hirsuta; controlled study; coral; drug cytotoxicity; drug structure; human; human cell; in vitro study; metabolite; neutrophil; nonhuman; nuclear magnetic resonance spectroscopy; animal; Anthozoa; chemical structure; chemistry; conformation; drug effects; neutrophil chemotaxis; Taiwan; tumor cell line; Animals; Anthozoa; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Humans; Models, Molecular; Molecular Conformation; Neutrophil Infiltration; Taiwan
Type
journal article