Podocalyxin於貓乳腺腫瘤之表現及其作為良惡性腫瘤生物標記之探討
The Expression and Malignancy Prediction of Podocalyxin as a Biomarker in Feline Mammary Gland Tumors
Date Issued
2006
Date
2006
Author(s)
Lin, Liang-Tao
DOI
zh-TW
Abstract
Mammary gland tumors (MGTs) are frequently encounted neoplasm in cats, and its ratio of malignancy is higher, so easy metastases cause poor prognosis. Many prognostic factors and biomarkers are studied and reported to assist the pathology diagnosis and prognosis. Podocalyxin was isolated in 1980’s from glomerular epithelium (podocyte) in rats, and is considered a function “anti-adhesion”. The function of anti-adhesion makes cells separate with each other and basement membrane. The objective of this study is to study the expression and malignancy prediction of Podocalyxin in feline mammary gland tumors. Thirty-two feline MGTs cases were retrospectively collected for basic information analysis and immunohistochemistry (IHC) of Podocalyxin and PCNA. The mean age of MGT affected cats was 9.7 year-old, and the first and second predisposing breed were Domestic Short Hair (DSH) (53.1%, 17/32) and Persian (21.8%, 7/32). The ratio of benign tumors and malignant tumors was 1:3. The result of IHC for Podocalyxin showed significant difference between malignant/metastastic neoplastic cells to normal/ hyperplastic cells (p < 0.05). The expression of Podocalyxin also had significant difference between hyperplastic/benign and normal cells. The expression for PCNA showed no significant difference between benignancy and malignancy. Based on the result, it is hypothesized that the expression of Podocalyxin is correlated to the malignance and metastasis, and Podocalyxin has a potential to be a prognostic biomarker in feline mammary gland tumors.
Subjects
貓
乳腺腫瘤
預後
Podocalyxin
cat
mammary gland tumor
prognosis
Type
thesis