Pulse pressure, aortic regurgitation and carotid atherosclerosis: A comparison between hypertensives and normotensives
Journal
International Journal of Clinical Practice
Journal Volume
60
Journal Issue
2
Pages
134
Date Issued
2006-02
Author(s)
URI
Abstract
Pulse pressure (PP) has often been associated with cardiovascular morbidity and mortality. Patients with aortic regurgitation (AR) often have increased PP. The aim of this study is to investigate the associations among PP, AR and extracranial carotid artery (ECCA) carotid atherosclerosis (CA) in hypertensives and age- and sex-matched normotensives. Two hundred and sixty-three hypertensive patients and 270 normotensive subjects from the Chin-Shan Community Cardiovascular Cohort participated in this study in 1996. CA, expressed as maximal common carotid artery intima-media thickness (IMT) ?75th percentile and ECCA plaque score >6, was measured using high-resolution B-mode ultrasonography. The presence of AR was assessed by echocardiography, and their relationships with CA were evaluated. Results showed measurements of CA significantly associated with increased PP. Presence of AR associated with CA, but this relationship was attenuated after controlling for age. Multivariate logistic regression analyses revealed that an ECCA score >6 significantly increase the risk in conjunction with PP, age and smoking in hypertensives. Correspondingly, CA increased with age, smoking and left ventricular hypertrophy on electrocardiography but not PP in normotensives. In conclusion, higher PP is strongly associated with CA in patients with hypertension. In terms of risk stratification, PP is more important in hypertensives than in normotensives which seem to imply that pulsatile haemodynamic component of BP is crucial in association with atherosclerosis. ? 2006 Blackwell Publishing Ltd.
Subjects
Aortic regurgitation; Carotid atherosclerosis; Hypertension; Pulse pressure
SDGs
Other Subjects
adult; age distribution; aged; aorta valve regurgitation; artery diameter; artery intima; artery media; article; atherosclerosis; atherosclerotic plaque; B scan; blood pressure measurement; cardiovascular risk; carotid artery obstruction; cigarette smoking; cohort analysis; common carotid artery; controlled study; disease association; echocardiography; electrocardiography; external carotid artery; female; heart left ventricle hypertrophy; hemodynamics; human; hypertension; major clinical study; male; morbidity; mortality; multivariate logistic regression analysis; priority journal; pulsatile flow; pulse pressure; risk assessment; scoring system; Aged; Aortic Valve Insufficiency; Atherosclerosis; Blood Pressure; Carotid Artery Diseases; Carotid Artery, External; Echocardiography; Female; Humans; Hypertension; Lipids; Male; Pulse; Risk Factors
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
49.pdf
Size
97.53 KB
Format
Adobe PDF
Checksum
(MD5):8b629bc0973b7661b58d267e7cafa231