Three-dimensional printed porous titanium screw with bioactive surface modification for bone–tendon healing: A rabbit animal model
Journal
International Journal of Molecular Sciences
Journal Volume
21
Journal Issue
10
Date Issued
2020
Author(s)
Huang, Y.-M.
Huang, C.-C.
Tsai, P.-I.
Yang, K.-Y.
Huang, S.-I.
Shen, H.-H.
Lai, H.-J.
Huang, S.-W.
Chen, S.-Y.
Lin, F.-H.
Chen, C.-Y.
Abstract
V) interference screw with chemically calcium phosphate surface modification technology to improve bone integration in the tibial tunnel. After chemical and heat treatment, the titanium screw formed a dense apatite layer on the metal surface in simulated body fluid. Twenty-seven New Zealand white rabbits were randomly divided into control and additive manufactured (AMD) screw groups. The long digital extensor tendon was detached and translated into a tibial plateau tunnel (diameter: 2.0 mm) and transfixed with an interference screw while the paw was in dorsiflexion. Biomechanical analyses, histological analyses, and an imaging study were performed at 1, 3, and 6 months. The biomechanical test showed that the ultimate pull-out load failure was significantly higher in the AMD screw group in all tested periods. Micro-computed tomography analyses revealed early woven bone formation in the AMD screw group at 1 and 3 months. In conclusion, AMD screws with bioactive surface modification improved bone ingrowth and enhanced biomechanical performance in a rabbit model.
SDGs
Type
journal article