GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
Journal
The American journal of psychiatry
Journal Volume
180
Journal Issue
10
Pages
723
Date Issued
2023
Author(s)
Docherty, Anna R
Mullins, Niamh
Ashley-Koch, Allison E
Qin, Xuejun
Coleman, Jonathan R I
Shabalin, Andrey
Kang, JooEun
Murnyak, Balasz
Wendt, Frank
Adams, Mark
Campos, Adrian I
DiBlasi, Emily
Fullerton, Janice M
Kranzler, Henry R
Bakian, Amanda V
Monson, Eric T
Rentería, Miguel E
Walss-Bass, Consuelo
Andreassen, Ole A
Behera, Chittaranjan
Bulik, Cynthia M
Edenberg, Howard J
Kessler, Ronald C
Mann, J John
Nurnberger, John I
Pistis, Giorgio
Streit, Fabian
Ursano, Robert J
Polimanti, Renato
Dennis, Michelle
Garrett, Melanie
Hair, Lauren
Harvey, Philip
Hauser, Elizabeth R
Hauser, Michael A
Huffman, Jennifer
Jacobson, Daniel
Madduri, Ravi
McMahon, Benjamin
Oslin, David W
Trafton, Jodie
Awasthi, Swapnil
Berrettini, Wade H
Bohus, Martin
Chang, Xiao
Chen, Wei J
Christensen, Erik D
Crow, Scott
Duriez, Philibert
Edwards, Alexis C
Fernández-Aranda, Fernando
Galfalvy, Hanga
Gandal, Michael
Gorwood, Philip
Guo, Yiran
Hafferty, Jonathan D
Hakonarson, Hakon
Halmi, Katherine A
Hishimoto, Akitoyo
Jain, Sonia
Jamain, Stéphane
Jiménez-Murcia, Susana
Johnson, Craig
Kaplan, Allan S
Kaye, Walter H
Keel, Pamela K
Kennedy, James L
Kim, Minsoo
Klump, Kelly L
Levey, Daniel F
Li, Dong
Lieb, Klaus
Lilenfeld, Lisa
Marshall, Christian R
Mitchell, James E
Okazaki, Satoshi
Otsuka, Ikuo
Pinto, Dalila
Powers, Abigail
Ramoz, Nicolas
Ripke, Stephan
Roepke, Stefan
Rozanov, Vsevolod
Scherer, Stephen W
Schmahl, Christian
Sokolowski, Marcus
Starnawska, Anna
Strober, Michael
Su, Mei-Hsin
Thornton, Laura M
Treasure, Janet
Ware, Erin B
Watson, Hunna J
Witt, Stephanie H
Woodside, D Blake
Yilmaz, Zeynep
Zillich, Lea
Adolfsson, Rolf
Agartz, Ingrid
Alda, Martin
Alfredsson, Lars
Appadurai, Vivek
Artigas, María Soler
Van der Auwera, Sandra
Azevedo, M Helena
Bass, Nicholas
Bau, Claiton H D
Baune, Bernhard T
Bellivier, Frank
Berger, Klaus
Biernacka, Joanna M
Bigdeli, Tim B
Binder, Elisabeth B
Boehnke, Michael
Boks, Marco P
Braff, David L
Bryant, Richard
Budde, Monika
Byrne, Enda M
Cahn, Wiepke
Castelao, Enrique
Cervilla, Jorge A
Chaumette, Boris
Corvin, Aiden
Craddock, Nicholas
Djurovic, Srdjan
Foo, Jerome C
Forstner, Andreas J
Frye, Mark
Gatt, Justine M
Giegling, Ina
Grabe, Hans J
Green, Melissa J
Grevet, Eugenio H
Grigoroiu-Serbanescu, Maria
Gutierrez, Blanca
Guzman-Parra, Jose
Hamshere, Marian L
Hartmann, Annette M
Hauser, Joanna
Heilmann-Heimbach, Stefanie
Hoffmann, Per
Ising, Marcus
Jones, Ian
Jones, Lisa A
Jonsson, Lina
Kahn, René S
Kelsoe, John R
Kendler, Kenneth S
Kloiber, Stefan
Koenen, Karestan C
Kogevinas, Manolis
Krebs, Marie-Odile
Landén, Mikael
Leboyer, Marion
Lee, Phil H
Levinson, Douglas F
Liao, Calwing
Lissowska, Jolanta
Mayoral, Fermin
McElroy, Susan L
McGrath, Patrick
McGuffin, Peter
McQuillin, Andrew
Mehta, Divya
Melle, Ingrid
Mitchell, Philip B
Molina, Esther
Morken, Gunnar
Nievergelt, Caroline
Nöthen, Markus M
O'Donovan, Michael C
Ophoff, Roel A
Owen, Michael J
Pato, Carlos
Pato, Michele T
Penninx, Brenda W J H
Potash, James B
Power, Robert A
Preisig, Martin
Quested, Digby
Ramos-Quiroga, Josep Antoni
Reif, Andreas
Ribasés, Marta
Richarte, Vanesa
Rietschel, Marcella
Rivera, Margarita
Roberts, Andrea
Roberts, Gloria
Rouleau, Guy A
Rovaris, Diego L
Sanders, Alan R
Schofield, Peter R
Schulze, Thomas G
Scott, Laura J
Serretti, Alessandro
Shi, Jianxin
Sirignano, Lea
Sklar, Pamela
Smeland, Olav B
Smoller, Jordan W
Sonuga-Barke, Edmund J S
Trzaskowski, Maciej
Tsuang, Ming T
Turecki, Gustavo
Vilar-Ribó, Laura
Vincent, John B
Völzke, Henry
Walters, James T R
Weickert, Cynthia Shannon
Weickert, Thomas W
Weissman, Myrna M
Williams, Leanne M
Wray, Naomi R
Zai, Clement C
Agerbo, Esben
Børglum, Anders D
Breen, Gerome
Demontis, Ditte
Erlangsen, Annette
Gelernter, Joel
Glatt, Stephen J
Hougaard, David M
Lewis, Cathryn M
Li, Qingqin S
Martin, Nicholas G
McIntosh, Andrew M
Medland, Sarah E
Mors, Ole
Nordentoft, Merete
Olsen, Catherine M
Porteous, David
Smith, Daniel J
Stahl, Eli A
Stein, Murray B
Wasserman, Danuta
Werge, Thomas
Whiteman, David C
Willour, Virginia
Coon, Hilary
Beckham, Jean C
Kimbrel, Nathan A
Ruderfer, Douglas M
Abstract
Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures.
Subjects
Biological Markers; Depressive Disorders; Genetics; Schizophrenia Spectrum and Other Psychotic Disorders; Self-Harm; Suicide
SDGs
Type
journal article