Higher Familial Loading Associates with Impaired Flush Response to Niacin Skin Patch among Schizophrenia Patients and Their Nonpsychotic Relatives
Date Issued
2007
Date
2007
Author(s)
Chang, Shu-Sen
DOI
zh-TW
Abstract
Objective: We previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known whether this abnormal niacin response is associated with familial loading for schizophrenia. This study compared niacin response in subjects from families with a sib-pair with schizophrenia (multiplex families) and those from families with only one member affected (simplex families).
Method: Subjects were schizophrenia patients and their first-degree relatives from multiplex families (311 probands with schizophrenia or schizoaffective disorder, 180 parents, and 52 non-affected siblings) and simplex families (176 schizophrenia probands, 260 parents, and 80 non-affected siblings) as well as 90 healthy comparison subjects. Niacin patches of three concentrations (0.001M, 0.01M, 0.1M) were applied to the forearm skin, and the flush response was rated at 5, 10 and 15 minutes, respectively, with a 4-point scale.
Results: More blunted response to topical niacin was shown in schizophrenia probands and their nonpsychotic relatives from multiplex families than their counterparts from simplex families. The greatest degree of differentiation between groups were revealed using 0.1M of niacin, with nonflush response in 23-57% of probands, 27-56% of parents, and 19-40% of siblings from multiplex families in contrast to 5-29%, 3-17% and 5-18% of their counterparts from simplex families, respectively, as well as in 0-30% of normal controls.
Conclusions: Flush response to skin niacin is more impaired in schizophrenia patients as well as their relatives from families with higher loading for schizophrenia. This finding might be useful for future genetic dissection of schizophrenia.
Subjects
精神分裂症
家庭負荷
無病親屬
菸鹼酸
皮膚測試
schizophrenia
familial loading
nonpsychotic relatives
niacin
skin test
Type
thesis
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