Surface Bioconjugate Chemistry Based on Vapor-Deposited Functionalized Poly-p-xylylene Coatings
Date Issued
2012
Date
2012
Author(s)
Liang, Wei-Chieh
Abstract
In past decades, the field of biointerface science, which is the reaction between surface and biomolecules, has been focused by chemists and biologists. Because more and more papers reported about surface biological chemistry, the functions of biomolecules and the interactions between biomolecules and environments has been discussed, and they were applied in various types of artificial materials. Moreover, according to growth of biointerface science, many new fields and technologies have been developed, such as biomedical, tissue engineering, micro total analysis systems (μTAS) ans biosensors. For the studying surface biological chemistry effectively, the selective conjugation onto surface is one of most important issue and, for the characteristics of enduing and stability, the covalence conjugation is superior. For the reason of the characteristics, the recently developing surface bioconjugations are bio-orthoogonal, fast, and site-specific, including the carbondimide reaction of amine and carboxylic acid, the thiol-ene reacton and the click chemistry. However, many artificial materials have no functional group such as metals and ceramics. It is the reason that a new field of surface modification has raised. Through chemistry vapor deposition, coating functional poly-p-xylene onto surface to modify surface is a one-step process, and it doesn’t have any inhibition for materials. Even, for the functional groups of biomolecules, papers dicected that various types of functional poly-p-xylene, such as Poly (4-ethynyl-p-xylylene-co-p-xylylene), Poly (4- aminomethyl-p-xylylene-co-p-xylylene), have been synthesized to conjugate the biomolecules and apply in many fields.
My research is that synthesize various functional [2,2] paracyclophane and use them to modify surface through chemistry vapor deposition. For the unique selective bioconjugtions, it can control the covalence of biomolecules and can be applied in biology fields such as controlling cell growth and anti-fouling. Moreover, we developed a new technology to control the chemical vapor deposition. Electric and deposition rate can control the deposition of functional poly-p-xylene onto specific area to achieve selective chemistry vapor deposition. For the new technology, surface modification can be precise, low limits, and applied extensively.
Subjects
biointerface science
surface bioconjugations
surface modification
functional poly-p-xylene
selective chemistry vapor deposition
Type
thesis
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