Prevalence of carbapenemase-producing Enterobacteriaceae and its impact on clinical outcomes at a teaching hospital in Taiwan
Journal
Journal of the Formosan Medical Association
Journal Volume
112
Journal Issue
8
Pages
492-496
Date Issued
2013
Author(s)
Abstract
Among 15 174 non-duplicated Enterobacteriaceae isolates, the prevalence of carbapenem-nonsusceptible Enterobacteriaceae (CNSE) was about 2.5% at a teaching hospital in Taiwan during 2010. Among 117 available isolates of CNSE, 8.6% carried genes encoding carbapenemases. Tigecycline and colistin were the most active agents against carbapenemase-producing and non-producing isolates. Patients infected with CNSE had an all-cause in-hospital mortality of 37.3%, and mortality was similar for infections from carbapenemase producers and non-producers (14-day mortality rates: 22.2% and 21.5%; 30-day mortality rates: 22.2% and 32.3%, respectively). Continuous surveillance of CNSE is recommended in Taiwan. ? 2012.
SDGs
Other Subjects
amikacin; carbapenem; carbapenemase; cefepime; cefotaxime; cephalosporin; colistin; flomoxef; imipenem; meropenem; moxifloxacin; quinoline derived antiinfective agent; tigecycline; abdominal infection; adult; aged; antibiotic sensitivity; article; bacteremia; bacterium isolate; controlled study; Enterobacteriaceae; Enterobacteriaceae infection; female; human; lower respiratory tract infection; major clinical study; male; minimum inhibitory concentration; mortality; nonhuman; prevalence; skin infection; soft tissue infection; Taiwan; teaching hospital; treatment outcome; urinary tract infection; carbapenemase; ertapenem-nonsusceptible Enterobacteriaceae; minimal inhibitory concentration; treatment outcomes; Aged; Aged, 80 and over; Bacterial Proteins; beta-Lactamases; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Hospitals, Teaching; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Taiwan; Treatment Outcome
Type
journal article