Predictability of visual function and nerve fiber layer thickness by cross-sectional areas of extraocular muscles in graves ophthalmopathy
Journal
American Journal of Ophthalmology
Journal Volume
151
Journal Issue
5
Pages
901-906
Date Issued
2011
Author(s)
Abstract
Purpose To evaluate the predictability of visual function and peripapillary nerve fiber layer thickness by cross-sectional areas of extraocular muscles in patients with Graves ophthalmopathy. Design Interventional case series. Methods The data on a total of 76 patients with Graves ophthalmopathy were collected, and the cross-sectional areas of 4 rectus muscles were calculated using computed tomographic images. This study measured the correlation between the cross-sectional area of all rectus muscles and the Hertel value, logarithm of the minimal angle of resolution (logMAR), mean deviation of retinal sensitivity, P100 value of visual evoked potential, total error of the Farnsworth-Munsell 100-hue color sensation test, and total thickness of the peripapillary nerve fiber layer thickness by optical coherence tomography. Results The cross-sectional area of all rectus muscles was significantly correlated with the mean deviation of retinal sensitivity (Pc = .08), the P 100 value of visual evoked potential (Pc < .01), and the total error of the 100-hue color sensation test (Pc < .01). However, the cross-sectional area of all rectus muscles was not significantly correlated with logMAR or proptosis, nor with the total thickness of the peripapillary nerve fiber layer. Conclusions For patients with Graves ophthalmopathy, the cross-sectional area of all rectus muscles was significantly correlated with visual function. The enlargement of extraocular muscles can be an early sign of optic neuropathy prior to perceived clinical symptoms. Furthermore, it is possible to predict visual function change using the cross-sectional area of all rectus muscles. ? 2011 Elsevier Inc.
SDGs
Other Subjects
adult; aged; article; clinical assessment tool; color sensation test; computer assisted tomography; evoked visual response; exophthalmos; extraocular muscle; female; Graves disease; human; image analysis; intervention study; major clinical study; male; optical coherence tomography; peripapillary nerve fiber layer thickness; priority journal; retinal sensitivity; sensitivity analysis; thickness; vision; visual system parameters
Publisher
Elsevier Inc.
Type
journal article