A convenient preparation of bis(4-methoxyphenyl)methanethiol and its application in the synthesis of biotin thioacid
Journal
Journal of the Chinese Chemical Society
Journal Volume
61
Journal Issue
6
Pages
707-710
Date Issued
2014
Author(s)
Abstract
Abstract We have established a facile protocol for the preparation of bis(4‐methoxyphenyl)methanethiol ( 4 ). Thiol 4 was used to prepare biotin thioester 7 which was later subjected to acidolysis to afford biotin thioacid ( 1b ) in high yield. Compound 1b represents a new biotinylating reagent worth exploring and its spectral data was reported for the first time.
Type
journal article