Effect of 30 bp deletion in the Epstein-Barr Virus LMP-1 gene on Prognosis of Nasopharyngeal Carcinoma Patients in Taiwan
Date Issued
2004
Date
2004
Author(s)
Chan, Yi-Chih
DOI
zh-TW
Abstract
Nasopharyngeal carcinoma ( NPC) is a common cancer in Chinese people, but it is rare in western countries. It has been demonstrated that Epstein-Barr virus-encoded latent membrane protein 1 ( LMP-1) can cause cellular transformation and activation of several intracellular signaling events. Several reports showed that EBV in the endemic areas of NPC commonly contains a mutant LMP-1 with 30 bp deletion in the C- terminal. This mutant LMP-1 has been shown to have an elevated transforming potential when compared with the wild type LMP-1 derived from B95-8 cells. In this study we amplified and sequenced the LMP-1 gene obtained from tissue of 130 NPC patients diagnosed and treated in National Taiwan University Hospital from 1994 to1999. The prevalence rate of mutant LMP-1 (NLMP-1 in this study) was 88.5% (115/130). In man and women, the presence of NLMP-1 was 93.3% (84/90) and 77.5% (31/40) respectively.
The clinical outcomes and pathological characteristics were analyzed in these two different groups of patients (LMP-1 with/without 30 bp deletion). The 5 –year overall survival rate in the BLMP-1 group (LMP-1 without 30 bp deletion) was significantly higher than the NLMP-1 group (72.4% vs. 61.0%, P=0.0067). In NLMP-1 group, patients older than 40 years of age had increase risk of dying from NPC. The presence of 30 bp deletion on the C-terminal of LMP1 was a significant variable associated with NPC-related death in multivariate Cox’s regression analysis (relative risk= 2.389, 95% CI= 1.218-4.685). It revealed that NLMP-1 gene is predominating in male patients, which may be related to the higher incidence and higher mortality rate in the male NPC patients in Taiwan.
Subjects
鼻咽癌
潛伏性膜狀蛋白-1
LMP-1
nasopharyngeal carcinoma
SDGs
Type
other
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